| | |  | | | | Record from Web of Science® | | | | | | |
| GENETIC ASSOCIATIONS WITH HUMAN LONGEVITY AT THE APOE AND ACE LOCI |
|
|
| Author(s): SCHACHTER F, FAUREDELANEF L, GUENOT F, ROUGER H, FROGUEL P, LESUEURGINOT L, COHEN D |
| Source: NATURE GENETICS Volume: 6 Issue: 1 Pages: 29-32 Published: JAN 1994 |
| Times Cited: 597 References: 36 |
| Abstract: In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n=338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p<0.001), while the frequency of the epsilon2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p<0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p<0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity. |
| Document Type: Article |
| Language: English |
| Reprint Address: SCHACHTER, F (reprint author), CTR ETUD POLYMORPHISME HUMAIN, 27 RUE JULIETTE DODU, F-75010 PARIS, FRANCE |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: MQ177 |
| ISSN: 1061-4036 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |