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| NEUROTROPHIN-3 ENHANCES SPROUTING OF CORTICOSPINAL TRACT DURING DEVELOPMENT AND AFTER ADULT SPINAL-CORD LESION |
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| Author(s): SCHNELL L, SCHNEIDER R, KOLBECK R, BARDE YA, SCHWAB ME |
| Source: NATURE Volume: 367 Issue: 6459 Pages: 170-173 Published: JAN 13 1994 |
| Times Cited: 591 References: 28 |
| Abstract: THE number of neurotrophic factors found in the central nervous system is rapidly growing, but their functions in vivo are largely unknown. In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration1-6. Here we study the effects of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the largest tract system leading from the brain to the spinal cord, the corticospinal tract (CST)7. The developing CST grows down the spinal cord during the first postnatal days and innervates its targets after a waiting period by collateral sprouting8-10. We find that NT-3 injected locally specifically enhances this sprouting, whereas BDNF has no effect. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST. The distance of growth of the sprouts is very restricted, but application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins'' results in long-distance regeneration of CST fibres. |
| Document Type: Article |
| Language: English |
| Reprint Address: SCHNELL, L (reprint author), UNIV ZURICH, BRAIN RES INST, AUGUST FOREL STR 1, CH-8029 ZURICH, SWITZERLAND |
Addresses:
1. MAX PLANCK INST PSYCHIAT, DEPT NEUROBIOCHEM, D-82152 MARTINSRIED, GERMANY |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MQ780 |
| ISSN: 0028-0836 |
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