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| PREDICTION OF BONE-DENSITY FROM VITAMIN-D RECEPTOR ALLELES |
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| Author(s): MORRISON NA, QI JC, TOKITA A, KELLY PJ, CROFTS L, NGUYEN TV, SAMBROOK PN, EISMAN JA |
| Source: NATURE Volume: 367 Issue: 6460 Pages: 284-287 Published: JAN 20 1994 |
| Times Cited: 1,221 References: 21 |
| Abstract: BONE density achieved in early adulthood is the major determinant of risk of osteoporotic fracture. Up to 60% of women1,2 suffer osteoporotic fractures as a result of low bone density2, which is under strong genetic control-3-6 acting through effects on bone turnover 7, 8. Here we show that common allelic variants in the gene encoding the vitamin D receptor9 can be used to predict differences in bone density, accounting for up to 75% of the total genetic effect on bone density in healthy individuals. The genotype associated with lower bone density was overrepresented in postmenopausal women with bone densities more than 2 standard deviations below values in young normal women. The molecular mechanisms by which bone density is regulated by the vitamin D receptor gene are not certain, although allelic differences in the 3' untranslated region may alter messenger RNA levels. These findings could open new avenues to the development and targeting of prophylactic interventions. It follows that other pathophysiological processes considered to be subject to complex multifactorial genetic regulation may also be modulated by a single gene with pleiotropic transcriptional actions. |
| Document Type: Article |
| Language: English |
| Reprint Address: MORRISON, NA (reprint author), ST VINCENTS HOSP, GARVAN INST MED RES, DIV BONE & MINERAL RES, DARLINGHURST, NSW 2010 AUSTRALIA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MR494 |
| ISSN: 0028-0836 |
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