| | |  | | | | Record from Web of Science® | | | | | | |
| ISSUES IN SEARCHING MOLECULAR SEQUENCE DATABASES |
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| Author(s): ALTSCHUL SF, BOGUSKI MS, GISH W, WOOTTON JC |
| Source: NATURE GENETICS Volume: 6 Issue: 2 Pages: 119-129 Published: FEB 1994 |
| Times Cited: 526 References: 93 |
| Abstract: Sequence similarity search programs are versatile tools for the molecular biologist, frequently able to identify possible DNA coding regions and to provide clues to gene and protein structure and function. While much attention had been paid to the precise algorithms these programs employ and to their relative speeds, there is a constellation of associated issues that are equally important to realize the full potential of these methods. Here, we consider a number of these issues, including the choice of scoring systems, the statistical significance of alignments, the masking of uninformative or potentially confounding sequence regions, the nature and extent of sequence redundancy in the databases and network access to similarity search services. |
| Document Type: Review |
| Language: English |
Addresses:
1. NIH, NATL LIB MED, NATL CTR BIOTECHNOL INFORMAT, BETHESDA, MD 20894 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: MU763 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |