| | |  | | | | Record from Web of Science® | | | | | | |
| OXYGEN RADICALS IN FOCAL CEREBRAL-ISCHEMIA |
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| Author(s): CHAN PH |
| Source: BRAIN PATHOLOGY Volume: 4 Issue: 1 Pages: 59-65 Published: JAN 1994 |
| Times Cited: 163 References: 54 |
| Abstract: Oxygen free radicals have been widely implicated in the pathogenesis of brain injury due to ischemia followed by reperfusion. The success of making transgenic animals overexpressing human CuZn-superoxide dismutase (CuZn-SOD) in brain cells allows researchers to discern the specific role of superoxide radicals in reperfusion injury after focal ischemia. It has been shown that increased brain levels of CuZn-SOD in transgenic mice protect neurons from ischemia/reperfusion injury. However, overexpression of CuZn-SOD does not provide neuronal protection in permanent focal ischemia in mice, when compared with non-transgenic mouse littermates. It is proposed that molecular genetic approaches of modifying antioxidant levels in the brain offer a unique tool for studying oxidative mechanisms in focal cerebral ischemia. |
| Document Type: Article |
| Language: English |
| Reprint Address: CHAN, PH (reprint author), UNIV CALIF SAN FRANCISCO, CNS INJURY & EDEMA RES CTR, DEPT NEUROSURG, SAN FRANCISCO, CA 94143 USA |
Addresses:
1. UNIV CALIF SAN FRANCISCO, CNS INJURY & EDEMA RES CTR, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA |
| Publisher: INT SOC NEUROPATHOLOGY, ISN JOURNAL PO BOX, CH-8033 ZURICH, SWITZERLAND |
| Subject Category: Clinical Neurology; Neurosciences; Pathology |
| IDS Number: MU866 |
| ISSN: 1015-6305 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |