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| METALLOPROTEASE AND SERINE-PROTEASE ARE INVOLVED IN CLEAVAGE OF CD43, CD44, AND CD16 FROM STIMULATED HUMAN GRANULOCYTES - INDUCTION OF CLEAVAGE OF L-SELECTIN VIA CD16 |
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| Author(s): BAZIL V, STROMINGER JL |
| Source: JOURNAL OF IMMUNOLOGY Volume: 152 Issue: 3 Pages: 1314-1322 Published: FEB 1 1994 |
| Times Cited: 108 References: 47 |
| Abstract: CD43, CD44, CD16, and L-selectin have been previously shown to be enzymatically cleaved from stimulated leukocytes. However, little is known about the enzymes involved in these processes. Here, metalloprotease(s) inhibitable by 1,10-phenanthroline together with serine protease(s) inhibitable by Nalpha-p-tosyl-L-lysine chloromethyl ketone and 3,4-dichloroisocoumarin are shown to be involved in the cleavage of CD43, CD44, and CD16 but not in the cleavage of L-selectin on granulocytes. in addition, mAbs that recognize these individual receptors and induce their specific cleavage did not initiate cleavage of the others. In one case only, L-selectin, cleavage was also triggered by mAbs interacting with CD16 (the low affinity FcgammaR). Thus, this mechanism represents a novel pathway of L-selectin cleavage induction. |
| Document Type: Article |
| Language: English |
Addresses:
1. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOCHEM & MOLEC BIOL, BOSTON, MA 02115 USA
2. CZECHOSLOVAK ACAD SCI, INST MOLEC GENET, PRAGUE 4, CZECH REPUBLIC |
| Publisher: AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Immunology |
| IDS Number: MV630 |
| ISSN: 0022-1767 |
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