| | |  | | | | Record from Web of Science® | | | | | | |
| MOLECULAR AND CELLULAR MECHANISMS OF GENERAL-ANESTHESIA |
|
|
| Author(s): FRANKS NP, LIEB WR |
| Source: NATURE Volume: 367 Issue: 6464 Pages: 607-614 Published: FEB 17 1994 |
| Times Cited: 1,145 References: 129 |
| Abstract: General anaesthetics are much more selective than Is usually appreciated and may act by binding to only a small number of targets in the central nervous system. At surgical concentrations their principal effects are on ligand;gated (rather than voltage-gated) ion channels, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia. Although the role of second messengers remains uncertain, it is now clear that anaesthetics act directly on proteins rather than on lipids. |
| Document Type: Review |
| Language: English |
| Reprint Address: FRANKS, NP (reprint author), IMPERIAL COLL SCI TECHNOL & MED, BLACKETT LAB, BIOPHYS SECT, PRINCE CONSORT RD, LONDON SW7 2BZ, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MW688 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |