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| ANTIGENIC DIVERSITY AND THE TRANSMISSION DYNAMICS OF PLASMODIUM-FALCIPARUM |
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| Author(s): GUPTA S, TRENHOLME K, ANDERSON RM, DAY KP |
| Source: SCIENCE Volume: 263 Issue: 5149 Pages: 961-963 Published: FEB 18 1994 |
| Times Cited: 122 References: 30 |
| Abstract: The average age of humans at their first infection with Plasmodium falciparum is typically less than 1 year in most endemic areas. This has been interpreted as evidence of the high transmissibility of the parasite, with the implication that control of malaria will require high levels of coverage with a potential vaccine. This interpretation is challenged by mathematical models that demonstrate that the long period required to develop immunity to malaria permits a high risk (or low average age) of infection even when parasite transmissibility is low. Patterns of seroconversion to five antigenically distinct isolates of P. falciparum in a highly malarious area of Papua New Guinea indicate that each is only mildly transmissible and that malaria, as a construct of several such independently transmitted strains, has a basic reproductive rate (or transmissibility) that is an order of magnitude lower than other estimates. |
| Document Type: Article |
| Language: English |
| Reprint Address: GUPTA, S (reprint author), UNIV OXFORD, DEPT ZOOL, OXFORD OX1 3PS, OXON ENGLAND |
Addresses:
1. PAPUA NEW GUINEA INST MED RES, MADANG, PAPUA N GUINEA
2. WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050 AUSTRALIA
3. IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOL, LONDON SW7 2BB, ENGLAND |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MX165 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |