| | |  | | | | Record from Web of Science® | | | | | | |
| EXTENSION OF LIFE-SPAN BY OVEREXPRESSION OF SUPEROXIDE-DISMUTASE AND CATALASE IN DROSOPHILA-MELANOGASTER |
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| Author(s): ORR WC, SOHAL RS |
| Source: SCIENCE Volume: 263 Issue: 5150 Pages: 1128-1130 Published: FEB 25 1994 |
| Times Cited: 859 References: 26 |
| Abstract: The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging. |
| Document Type: Article |
| Language: English |
| Reprint Address: ORR, WC (reprint author), SO METHODIST UNIV, DEPT BIOL SCI, DALLAS, TX 75275 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MX759 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |