| | |  | | | | Record from Web of Science® | | | | | | |
| REPLACEMENT OF DISEASED MOUSE-LIVER BY HEPATIC CELL TRANSPLANTATION |
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| Author(s): RHIM JA, SANDGREN EP, DEGEN JL, PALMITER RD, BRINSTER RL |
| Source: SCIENCE Volume: 263 Issue: 5150 Pages: 1149-1152 Published: FEB 25 1994 |
| Times Cited: 323 References: 18 |
| Abstract: Adult liver has the unusual ability to fully regenerate after injury. Although regeneration is accomplished by the division of mature hepatocytes, the replicative potential of these cells is unknown. Here, the replicative capacity of adult liver cells and their medical usefulness as donor cells for transplantation were investigated by transfer of adult mouse liver cells into transgenic mice that display an endogenous defect in hepatic growth potential and function. The transplanted liver cell populations replaced up to 80 percent of the diseased recipient liver. These findings demonstrate the enormous growth potential of adult hepatocytes, indicating the feasibility of liver cell transplantation as a method to replace lost or diseased hepatic parenchyma. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV PENN, SCH VET MED, DEPT ANIM BIOL, PHILADELPHIA, PA 19104 USA
2. UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA
3. UNIV CINCINNATI, COLL MED, DEPT PEDIAT, CINCINNATI, OH 45229 USA
4. UNIV CINCINNATI, COLL MED, CHILDRENS HOSP RES FDN, CINCINNATI, OH 45229 USA
5. UNIV WASHINGTON, HOWARD HUGHES MED INST, SEATTLE, WA 98195 USA
6. UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: MX759 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |