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| MAST-CELL PHAGOCYTOSIS OF FIMH-EXPRESSING ENTEROBACTERIA |
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| Author(s): MALAVIYA R, ROSS EA, MACGREGOR JI, IKEDA T, LITTLE JR, JAKSCHIK BA, ABRAHAM SN |
| Source: JOURNAL OF IMMUNOLOGY Volume: 152 Issue: 4 Pages: 1907-1914 Published: FEB 15 1994 |
| Times Cited: 113 References: 52 |
| Abstract: Most studies of mast cells have been directed at their role in the pathophysiology of IgE-mediated allergic reactions with little recognition of their participation in bacterial infections. We report that mast cells can specifically bind FimH, a mannose-binding subunit on type 1 fimbriae expressed by Escherichia coli and other enterobacteria. This interaction triggers mast cell phagocytosis and killing of the bacteria within acidified vacuoles and through the release of superoxide anions. Also, in view of the fact that mast cells have the capacity to release inflammatory mediators and are particularly abundant in the skin, mucosal surfaces, and around blood vessels, we suggest that these cells play an important role in host defense against microbial infection. |
| Document Type: Article |
| Language: English |
Addresses:
1. WASHINGTON UNIV, JEWISH HOSP ST LOUIS, MED CTR, DEPT PATHOL, ST LOUIS, MO 63110 USA
2. WASHINGTON UNIV, SCH MED, DEPT PATHOL, ST LOUIS, MO 63110 USA
3. WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA
4. WASHINGTON UNIV, ST LOUIS, MO USA
5. JEWISH HOSP ST LOUIS, DEPT PATHOL, ST LOUIS, MO 63110 USA
6. JEWISH HOSP ST LOUIS, DEPT MED, ST LOUIS, MO 63110 USA |
| Publisher: AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Immunology |
| IDS Number: MY844 |
| ISSN: 0022-1767 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |