| MOLECULAR MECHANISMS OF TUMOR NECROSIS FACTOR-INDUCED CYTOTOXICITY - WHAT WE DO UNDERSTAND AND WHAT WE DO NOT |
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| Author(s): BEYAERT R, FIERS W |
| Source: FEBS LETTERS Volume: 340 Issue: 1-2 Pages: 9-16 Published: FEB 28 1994 |
| Times Cited: 210 References: 87 |
| Abstract: Although TNF plays an important role in several physiological and pathological conditions, the hallmark of this important cytokine has been its selective cytotoxic activity on tumor cells. Since its cloning in 1984, understanding of how TNF selectively kills tumor cells has been the subject of research in many laboratories. Here we review TNF-induced post-receptor signaling mechanisms which seem to be involved in the pathway to cytotoxicity. |
| Document Type: Review |
| Language: English |
Addresses:
1. STATE UNIV GHENT, MOLEC BIOL LAB, B-9000 GHENT, BELGIUM |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: MZ670 |
| ISSN: 0014-5793 |