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| SUPERFICIAL PHOTODYNAMIC THERAPY WITH TOPICAL 5-AMINOLEVULINIC ACID FOR SUPERFICIAL PRIMARY AND SECONDARY SKIN-CANCER |
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| Author(s): CAIRNDUFF F, STRINGER MR, HUDSON EJ, ASH DV, BROWN SB |
| Source: BRITISH JOURNAL OF CANCER Volume: 69 Issue: 3 Pages: 605-608 Published: MAR 1994 |
| Times Cited: 218 References: 23 |
| Abstract: Between January 1991 and December 1992 a phase I trial of superficial photodynamic therapy (PDT) using topical application of 5-aminolaevulinic acid (ALA) was undertaken to treat Bowen's disease, superficial basal cell carcinomas (BCCs) and metastatic skin secondaries from breast (adenocarcinoma) or pinna (squamous cell carcinoma). Promising results were obtained with 36 areas of Bowen's disease, with a complete response rate of 89% at a median follow-up of 18 months. The treatment of BCCs was less successful, with 50% complete responses in 16 lesions at a median follow-up of 17 months. Metastatic nodules responded poorly. The treatment was well tolerated and discomfort during light irradiation could be reduced by prior application of 'Emla' cream. Lesions wept for 1-2 weeks following treatment and healed over a period of approximately 2 months. For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies. Further work is required to improve the results with BCCs. |
| Document Type: Article |
| Language: English |
| Reprint Address: CAIRNDUFF, F (reprint author), COOKRIDGE HOSP, CTR REG RADIOTHERAPY, ACAD UNIT RADIOTHERAPY, TUNBRIDGE BLDG, LEEDS LS16 6QB, W YORKSHIRE ENGLAND |
Addresses:
1. UNIV LEEDS, DEPT CLIN MED, ACAD UNIT MED PHYS, LEEDS LS2 9JT, W YORKSHIRE ENGLAND
2. UNIV LEEDS, DEPT BIOCHEM & MOLEC BIOL, LEEDS LS2 9JT, W YORKSHIRE ENGLAND |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Oncology |
| IDS Number: NA001 |
| ISSN: 0007-0920 |
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