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| SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS |
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| Author(s): FINER JT, SIMMONS RM, SPUDICH JA |
| Source: NATURE Volume: 368 Issue: 6467 Pages: 113-119 Published: MAR 10 1994 |
| Times Cited: 886 References: 45 |
| Abstract: A new in vitro assay using a feedback enhanced laser trap system allows direct measurement of force and displacement that results from the interaction of a single myosin molecule with a single suspended actin filament. Discrete stepwise movements averaging ai nm were seen under conditions of low load, and single force transients averaging 3-4 pN were measured under isometric conditions. The magnitudes of the single forces and displacements are consistent with predictions of the conventional swinging-crossbridge model of muscle contraction. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, SCH MED, BECKMAN CTR, DEPT BIOCHEM, STANFORD, CA 94305 USA
2. STANFORD UNIV, SCH MED, BECKMAN CTR, DEPT BIOL, STANFORD, CA 94305 USA
3. KINGS COLL LONDON, RANDALL INST, MRC MUSCLE & CELL MOTIL UNIT, LONDON WC2B 5RL, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: NA030 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |