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| A 6.5-MB YEAST ARTIFICIAL CHROMOSOME CONTIG INCORPORATING 33 DNA MARKERS ON THE HUMAN X-CHROMOSOME AT XQ122 |
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| Author(s): VETRIE D, KENDALL E, COFFEY A, HASSOCK S, COLLINS J, TODD C, LEHRACH H, BOBROW M, BENTLEY DR, HARRIS A |
| Source: GENOMICS Volume: 19 Issue: 1 Pages: 42-47 Published: JAN 1 1994 |
| Times Cited: 30 References: 45 |
| Abstract: The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome, (C) 1994 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: VETRIE, D (reprint author), UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, DIV MED & MOLEC GENET, PAEDIAT RES UNIT, GUYS CAMPUS, LONDON SE1 9RT, ENGLAND |
Addresses:
1. IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND
2. JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biotechnology & Applied Microbiology; Genetics & Heredity |
| IDS Number: NA601 |
| ISSN: 0888-7543 |
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