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| EFFECT OF HIGH-DOSE VITAMIN-C ON URINARY OXALATE LEVELS |
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| Author(s): WANDZILAK TR, DANDRE SD, DAVIS PA, WILLIAMS HE |
| Source: JOURNAL OF UROLOGY Volume: 151 Issue: 4 Pages: 834-837 Published: APR 1994 |
| Times Cited: 61 References: 22 |
| Abstract: The effect of high dose ascorbate on urinary oxalate levels in healthy adults was investigated using a modified ion chromatography method. Subjects ingested 1, 5 and 10 gm. supplemental ascorbate per day for 5 days, separated by 5 days of no supplementation. Urine ascorbate levels demonstrated variable increases with ascorbate supplementation. Ascorbate added directly to urine in vitro resulted in statistically significant but modest increases in measured oxalate. Addition of 5.68 mmol./l. ascorbate increased measured urinary oxalate by 36 mu mol./l., implying conversion of ascorbate to oxalate during analysis. Measurement of 24-hour urinary oxalate levels with 5 and 10 gm. ascorbate per day showed similar, modest increases, which could be entirely accounted for by oxalate production during analytical procedures. Thus, no genuine increase in urinary oxalate was demonstrable despite a greatly increased ascorbate intake. |
| Document Type: Article |
| Language: English |
| Reprint Address: WANDZILAK, TR (reprint author), UNIV CALIF DAVIS, DEPT UROL, DIV CLIN NUTR & METAB, DAVIS, CA 95616 USA |
Addresses:
1. UNIV CALIF DAVIS, DEPT INTERNAL MED, DIV GEN MED, DAVIS, CA USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Urology & Nephrology |
| IDS Number: NA970 |
| ISSN: 0022-5347 |
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