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| MURINE DENDRITIC CELLS PULSED IN-VITRO WITH TUMOR-ANTIGEN INDUCE TUMOR RESISTANCE IN-VIVO |
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| Author(s): FLAMAND V, SORNASSE T, THIELEMANS K, DEMANET C, BAKKUS H, BAZIN H, TIELEMANS F, LEO O, URBAIN J, MOSER M |
| Source: EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 24 Issue: 3 Pages: 605-610 Published: MAR 1994 |
| Times Cited: 254 References: 32 |
| Abstract: The aim of this work is to induce tumor resistance to a B cell lymphoma in BALB/c mice using elements of the immune system. It has indeed been shown by us and by others that antigen-presenting cells (APC) like dendritic cells can induce efficient immune responses and can even substitute for Freund's adjuvant. Here we show that mice immunized with syngeneic dendritic cells pulsed in vitro with tumor antigen (BCL1 idiotype expressed by lymphoma cells) are protected against a subsequent tumor inoculation. The in vivo resistance can be correlated with the induction of a humoral response specific for the idiotype expressed by the tumor. No such protection can be achieved when B cells are used as APC. These data show that effector cells in tumor-bearing animals can be recruited and activated using dendritic cells, providing long-lasting immune surveillance. |
| Document Type: Article |
| Language: English |
Addresses:
1. FREE UNIV BRUSSELS, DEPT MOLEC BIOL, PHYSIOL ANIM LAB, B-1640 RHODE ST GENESE, BELGIUM
2. FREE UNIV BRUSSELS, SCH MED, DIV HEMATOL IMMUNOL, B-1000 BRUSSELS, BELGIUM
3. UNIV CATHOLIQUE LOUVAIN, FAC MED, UNITE IMMUNOL EXPTL, B-1200 BRUSSELS, BELGIUM |
| Publisher: VCH PUBLISHERS INC, 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 |
| Subject Category: Immunology |
| IDS Number: NB718 |
| ISSN: 0014-2980 |
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