| | |  | | | | Record from Web of Science® | | | | | | |
| PROTECTION FROM FAS-MEDIATED APOPTOSIS BY A SOLUBLE FORM OF THE FAS MOLECULE |
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| Author(s): CHENG JH, ZHOU T, LIU CD, SHAPIRO JP, BRAUER MJ, KIEFER MC, BARR PJ, MOUNTZ JD |
| Source: SCIENCE Volume: 263 Issue: 5154 Pages: 1759-1762 Published: MAR 25 1994 |
| Times Cited: 816 References: 23 |
| Abstract: Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types. Molecular cloning and nucleotide sequence analysis revealed a human Fas messenger RNA variant capable of encoding a soluble Fas molecule lacking the transmembrane domain because of the deletion of an exon encoding this region. The expression of soluble Fas was confirmed by flow cytometry and immunocytochemical analysis. Supernatants from cells transfected with the variant messenger RNA blocked apoptosis induced by the antibody to Fas. Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ALABAMA, BIRMINGHAM, AL 35294 USA
2. VET ADM MED CTR, BIRMINGHAM, AL 35294 USA
3. LXR BIOTECHNOL INC, RICHMOND, CA 94804 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: NC040 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |