| | |  | | | | Record from Web of Science® | | | | | | |
| FREQUENT MICROSATELLITE INSTABILITY IN PRIMARY SMALL-CELL LUNG-CANCER |
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| Author(s): MERLO A, MABRY M, GABRIELSON E, VOLLMER R, BAYLIN SB, SIDRANSKY D |
| Source: CANCER RESEARCH Volume: 54 Issue: 8 Pages: 2098-2101 Published: APR 15 1994 |
| Times Cited: 230 References: 36 |
| Abstract: Alterations in microsatellite sequences characterize hereditary nonpolyposis colorectal cancer. This microsatellite instability is due in some kindreds to a germline mutation of the mismatch repair gene hMSH2 on chromosome 2p. Although microsatellite alterations have been reported in other hereditary nonpolyposis colorectal cancer-associated tumors including endometrial and gastric cancers, such changes were not detected in most other major neoplasms. We found that 15 of 33 (45%) primary small cell lung cancers, tumors not found in the hereditary nonpolyposis colorectal cancer syndrome, displayed alterations of microsatellite loci which consisted of deletions or expansions of (CA)(n) dinucleotide repeats. In 8 of these 15 neoplasms, microsatellite instability was detected in more than 10% of all tested alleles. However, small cell lung cancers that revealed instability contained widespread allelic loss and had a uniformly poor prognosis. These results expand considerably the known spectrum of tumors with microsatellite instability. |
| Document Type: Note |
| Language: English |
Addresses:
1. JOHNS HOPKINS UNIV, SCH MED, DEPT OTOLARYNGOL, DIV HEAD & NECK CANC RES, BALTIMORE, MD 21205 USA
2. JOHNS HOPKINS UNIV, SCH MED, DEPT ONCOL, BALTIMORE, MD 21205 USA
3. JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA
4. DUKE UNIV, DEPT PATHOL, DURHAM, NC 27706 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: NE849 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |