| | |  | | | | Record from Web of Science® | | | | | | |
| CELLULAR AND MOLECULAR-BIOLOGY OF ALZHEIMERS-DISEASE AND ANIMAL-MODELS |
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| Author(s): PRICE DL, SISODIA SS |
| Source: ANNUAL REVIEW OF MEDICINE Volume: 45 Pages: 435-446 Published: 1994 |
| Times Cited: 80 References: 77 |
| Abstract: Alzheimer's disease (AD), the most common dementing disorder of late life, is a major cause of disability and death in the elderly. Neurobiological, genetic, and molecular studies have defined the vulnerable neural systems, abnormalities in cytoskeletal proteins in neurons, the biology of the beta-amyloid precursor protein (APP) and beta-amyloid (A beta, beta A4), and several APP mutations linked to the disease. More recently, investigators have begun to develop animal models essential for delineating pathogenetic mechanisms and for developing and testing new therapies for treating AD in humans. This review focuses primarily on recent progress in investigation of animal models of AD (including aged nonhuman primates and transgenic mice), which have begun to clarify some of the questions raised by investigation of the disease in humans. |
| Document Type: Review |
| Language: English |
| Reprint Address: PRICE, DL (reprint author), JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA |
Addresses:
1. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA
2. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA
3. JOHNS HOPKINS UNIV, SCH MED, NEUROPATHOL LAB, BALTIMORE, MD 21205 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Medicine, General & Internal |
| IDS Number: NF168 |
| ISSN: 0066-4219 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |