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| TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE - STRAIN VARIATION AND THE SPECIES BARRIER |
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| Author(s): BRUCE M, CHREE A, MCCONNELL I, FOSTER J, PEARSON G, FRASER H |
| Source: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES Volume: 343 Issue: 1306 Pages: 405-411 Published: MAR 29 1994 |
| Times Cited: 306 References: 29 |
| Abstract: Transmissions of bovine spongiform encephalopathy (BSE) from seven unrelated cattle sources have given remarkably uniform disease characteristics in mice, differing from over twenty previous and contemporary transmissions of sheep and goat scrapie. Transmissions to mice of spongiform encephalopathy from six species (including sheep and goats) which have been experimentally or naturally infected with BSE have given similar results to direct BSE transmissions from cattle. Therefore the BSE agent has retained its identity when passaged through a range of species and the 'donor' species has little specific influence on disease characteristics in mice, adding to evidence for an agent-specific informational molecule. On transmission of BSE or scrapie to mice the incubation periods are long compared with subsequent mouse-to-mouse passages (the 'species barrier'). Contributing factors include a low efficiency of infection on interspecies transmission, the apparent failure of intracerebrally injected 'foreign inoculum to establish infection directly in mouse brain and the selection of variant strains of agent which replicate most readily in the new host species. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: BRUCE, M (reprint author), AFRC, INST ANIM HLTH, W MAINS RD, EDINBURGH EH9 3JF, MIDLOTHIAN SCOTLAND |
Addresses:
1. MRC, NEUROPATHOGENESIS UNIT, EDINBURGH EH9 3JF, MIDLOTHIAN SCOTLAND
2. UNIV BRISTOL, SCH VET SCI, BRISTOL BS18 7DU, AVON ENGLAND |
| Publisher: ROYAL SOC LONDON, 6 CARLTON HOUSE TERRACE, LONDON, ENGLAND SW1Y 5AG |
| Subject Category: Biology |
| IDS Number: NF689 |
| ISSN: 0962-8436 |
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