| SEQUENTIAL PROTEIN-KINASE REACTIONS CONTROLLING CELL-GROWTH AND DIFFERENTIATION |
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| Author(s): JOHNSON GL, VAILLANCOURT RR |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 6 Issue: 2 Pages: 230-238 Published: APR 1994 |
| Times Cited: 297 References: 72 |
| Abstract: Sequential protein kinase reactions involve the phosphorylation and activation of multiple kinases in a pathway. The growth factor receptor tyrosine kinase regulation of the mitogen-activated protein kinase (MAPK) pathway was defined in 1993. The MAPK pathway involves sequential protein kinase reactions. Notable advances were made in defining tyrosine kinase receptor regulation of Ras, and these discoveries were combined with the identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP. |
| Document Type: Article |
| Language: English |
| Reprint Address: JOHNSON, GL (reprint author), NATL JEWISH CTR IMMUNOL & RESP MED, DIV BASIC SCI, 1400 JACKSON ST, DENVER, CO 80206 USA |
Addresses:
1. UNIV COLORADO, SCH MED, DENVER, CO 80262 USA |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Cell Biology |
| IDS Number: NG021 |
| ISSN: 0955-0674 |