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| A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES |
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| Author(s): KAMB A, GRUIS NA, WEAVERFELDHAUS J, LIU QY, HARSHMAN K, TAVTIGIAN SV, STOCKERT E, DAY RS, JOHNSON BE, SKOLNICK MH |
| Source: SCIENCE Volume: 264 Issue: 5157 Pages: 436-440 Published: APR 15 1994 |
| Times Cited: 2,271 References: 28 |
| Abstract: A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (pl 6) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte. Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues. |
| Document Type: Article |
| Language: English |
| Reprint Address: KAMB, A (reprint author), MYRIAD GENET INC, SALT LAKE CITY, UT 84108 USA |
Addresses:
1. NCI, LUNG CANC BIOL SECT, BETHESDA, MD 20889 USA
2. MYRIAD GENET INC, SALT LAKE CITY, UT 84108 USA
3. MEM SLOAN KETTERING CANC CTR, LUDWIG INST CANC RES, NEW YORK, NY 10021 USA
4. CROSS CANC INST, DEPT MED, EDMONTON T6G 1Z2, ALBERTA CANADA
5. UNIV UTAH, MED CTR, DEPT MED INFORMAT, SALT LAKE CITY, UT 84112 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: NG194 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |