| | |  | | | | Record from Web of Science® | | | | | | |
| PATHOGENIC DIVERSITY OF SIMIAN IMMUNODEFICIENCY VIRUSES |
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| Author(s): HIRSCH VM, JOHNSON PR |
| Source: VIRUS RESEARCH Volume: 32 Issue: 2 Pages: 183-203 Published: MAY 1994 |
| Times Cited: 97 References: 73 |
| Abstract: The SIV family is a diverse group of viruses that vary considerably in pathogenesis and virulence in their natural host species or macaques. Although the disease induced by the SIVsm subtype in particular is remarkably similar to human AIDS, it must be remembered that this is an experimental animal model. Therefore, although the pathogenesis of SIVsm (and other viruses) in macaques offers an relevant animal model for pathogenesis and vaccine trials, the interactions of these viruses in their natural host, and virus-, or host-specific effects have been poorly characterized. This animal model offers a unique opportunity to study the details of the pathogenesis of immunodeficiency and to define host and viral factors responsible for disease progression. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: HIRSCH, VM (reprint author), NIAID, INFECT DIS LAB, IMMUNODEFICIENCY VIRUSES SECT, 12441 PARKLAWN DR, ROCKVILLE, MD 20852 USA |
Addresses:
1. OHIO STATE UNIV, CHILDRENS HOSP RES FDN, DEPT PEDIAT, COLUMBUS, OH 43205 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Virology |
| IDS Number: NL495 |
| ISSN: 0168-1702 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |