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| BENIGN HUMAN ENTEROVIRUS BECOMES VIRULENT IN SELENIUM-DEFICIENT MICE |
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| Author(s): BECK MA, KOLBECK PC, ROHR LH, SHI Q, MORRIS VC, LEVANDER OA |
| Source: JOURNAL OF MEDICAL VIROLOGY Volume: 43 Issue: 2 Pages: 166-170 Published: JUN 1994 |
| Times Cited: 88 References: 23 |
| Abstract: Coxsackieviruses have been implicated as possible co-factors in the etiology of the selenium (Se)-responsive cardiomyopathy known as Keshan disease. Here we report that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3/0), which causes no pathology in the hearts of Se-adequate mice, induces extensive cardiac pathology in Se-deficient mice. CVB3/0 recovered from the hearts of Se-deficient mice inoculated into Se-adequate mice induced significant heart damage, suggesting mutation of the virus to a virulent genotype. We demonstrate the important role of host nutritional status in determining the severity of a viral infection. (C) 1994 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: BECK, MA (reprint author), UNIV N CAROLINA, FRANK PORTER GRAHAM CHILD DEV CTR, CB 8180, 105 SMITH LEVEL RD, CHAPEL HILL, NC 27599 USA |
Addresses:
1. UNIV NEBRASKA, MED CTR, DEPT PATHOL & MICROBIOL, OMAHA, NE USA
2. USDA ARS, BELTSVILLE AGR RES CTR, HUMAN NUTR RES CTR, BELTSVILLE, MD 20705 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Virology |
| IDS Number: NM387 |
| ISSN: 0146-6615 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |