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| LACK OF NEUROTROPHIN-3 LEADS TO DEFICIENCIES IN THE PERIPHERAL NERVOUS-SYSTEM AND LOSS OF LIMB PROPRIOCEPTIVE AFFERENTS |
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| Author(s): ERNFORS P, LEE KF, KUCERA J, JAENISCH R |
| Source: CELL Volume: 77 Issue: 4 Pages: 503-512 Published: MAY 20 1994 |
| Times Cited: 482 References: 59 |
| Abstract: Neurotrophin-3-deficient (NT-3-deficient) mice were generated by gene targeting. Mutant mice displayed severe movement defects of the limbs, and most died shortly after birth. Substantial portions of peripheral sensory and sympathetic neurons were lost while motor neurons were not affected. Significantly, spinal proprioceptive afferents and their peripheral sense organs (muscle spindles and Golgi tendon organs) were completely absent in homozygous mutant mice. This correlated with a loss of parvalbumin and carbonic anhydrase-positive neurons in the dorsal root ganglion. No gross abnormalities were seen in Pacinian corpuscles, cutaneous afferents containing substance P and calcitonin gene-related peptide, and deep nerve fibers in the joint capsule and tendon. Importantly, the number of muscle spindles in heterozygous mutant mice was half of that in control mice, indicating that NT-3 is present at limiting concentrations in the embryo. |
| Document Type: Article |
| Language: English |
| Reprint Address: ERNFORS, P (reprint author), WHITEHEAD INST BIOMED RES, 9 CAMBRIDGE CTR, CAMBRIDGE, MA 02142 USA |
Addresses:
1. MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA
2. BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: NM832 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |