| | |  | | | | Record from Web of Science® | | | | | | |
| FUSION OF PAX7 TO FKHR BY THE VARIANT T(1,13)(P36,Q14) TRANSLOCATION IN ALVEOLAR RHABDOMYOSARCOMA |
|
|
| Author(s): DAVIS RJ, DCRUZ CM, LOVELL MA, BIEGEL JA, BARR FG |
| Source: CANCER RESEARCH Volume: 54 Issue: 11 Pages: 2869-2872 Published: JUN 1 1994 |
| Times Cited: 301 References: 20 |
| Abstract: Although the t(2;13)(q35;q14) translocation has been found in most cases of the pediatric cancer alveolar rhabdomyosarcoma, several cases have been reported with a variant t(1;13)(p36;q14) translocation. Our findings indicate that this t(1;13) rearranges PAX7 on chromosome 1 and fuses it to FKHR on chromosome 13. This fusion results in a chimeric transcript consisting of 5' PAX7 and 3' FKHR regions, which is similar to the 5' PAX3-3' FKHR transcript formed by the t(2;13). The 5' PAX3 and PAX7 regions encode related DNA binding domains, and therefore we postulate that these translocations create similar chimeric transcription factors that alter expression of a common group of target genes. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV PENN, SCH MED, DEPT LAB MED & PATHOL, PHILADELPHIA, PA 19104 USA
2. CHILDRENS HOSP PHILADELPHIA, DIV HUMAN GENET & MOLEC BIOL, PHILADELPHIA, PA 19104 USA
3. UNIV VIRGINIA, DEPT PATHOL, CHARLOTTESVILLE, VA 22908 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: NN724 |
| ISSN: 0008-5472 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |