| | |  | | | | Record from Web of Science® | | | | | | |
| ALCOHOL, IMMUNOMODULATION, AND DISEASE |
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| Author(s): WATSON RR, BORGS P, WITTE M, MCCUSKEY RS, LANTZ C, JOHNSON MI, MUFTI SI, EARNEST DL |
| Source: ALCOHOL AND ALCOHOLISM Volume: 29 Issue: 2 Pages: 131-139 Published: MAR 1994 |
| Times Cited: 51 References: 52 |
| Abstract: Recent research findings point to a spectrum of alcohol-induced immune dysfunctions in animal models and humans. Use of alcohol in vivo causes abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity, including lymphocytes, Kupffer cells and other macrophages, as well as the endothelium of blood vessels and lymphatics. Regulatory cytokines and neuroendocrine factors can mediate some of these immunomodulatory effects which may be further re-phased, exaggerated or unbalanced by other drugs of misuse. A variety of animal models is available to study acute and chronic alcoholism, non-alcohol drug misuse, AIDS as well as other opportunistic infections, and neoplasias, which hold promise of clarifying the role of alcohol as an immunomodulator. |
| Document Type: Review |
| Language: English |
| Reprint Address: WATSON, RR (reprint author), UNIV ARIZONA, SCH MED, DEPT FAMILY & COMMUNITY MED, ALCOHOL RES CTR, TUCSON, AZ 85724 USA |
Addresses:
1. UNIV ARIZONA, SCH MED, DEPT SURG, TUCSON, AZ 85724 USA
2. UNIV ARIZONA, SCH MED, DEPT ANAT, TUCSON, AZ 85724 USA
3. UNIV ARIZONA, SCH MED, DEPT PEDIAT, TUCSON, AZ 85724 USA
4. UNIV ARIZONA, SCH MED, DEPT PHARMACOL & TOXICOL, TUCSON, AZ 85724 USA
5. UNIV ARIZONA, SCH MED, DEPT BUNKYO KU, TUCSON, AZ 85724 USA |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Substance Abuse |
| IDS Number: NN783 |
| ISSN: 0735-0414 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |