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| A SIB-PAIR APPROACH TO INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI |
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| Author(s): FULKER DW, CARDON LR |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 54 Issue: 6 Pages: 1092-1103 Published: JUN 1994 |
| Times Cited: 121 References: 26 |
| Abstract: An interval mapping procedure based on the sib-pair method of Haseman and Elston is developed, and simulation studies are carried out to explore its properties. The procedure is analogous to other interval mapping procedures used with experimental material, such as plants and animals, and yields very similar results in terms of the location and effect size of a quantitative trait locus (QTL). The procedure offers an advantage over the conventional Haseman and Elston approach, in terms of power, and provides useful information concerning the location of a QTL. Because of its simplicity, the method readily lends itself to the analysis of selected samples for increased power and the evaluation of multilocus models of complex phenotypes. |
| Document Type: Article |
| Language: English |
| Reprint Address: FULKER, DW (reprint author), UNIV COLORADO, INST BEHAV GENET, BOULDER, CO 80309 USA |
Addresses:
1. STANFORD UNIV, DEPT MATH, STANFORD, CA 94305 USA
2. SRI INT, HLTH SCI SECT, STANFORD, CA USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: NP053 |
| ISSN: 0002-9297 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |