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| T-CELLS FROM THE PERIPHERAL-BLOOD OF CELIAC-DISEASE PATIENTS RECOGNIZE GLUTEN ANTIGENS WHEN PRESENTED BY HLA-DR, HLA-DQ, OR HLA-DP MOLECULES |
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| Author(s): GJERTSEN HA, SOLLID LM, EK J, THORSBY E, LUNDIN KEA |
| Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 39 Issue: 6 Pages: 567-574 Published: JUN 1994 |
| Times Cited: 44 References: 33 |
| Abstract: Coeliac disease (CD) is a T-cell mediated immunological disease of the small intestine which is precipitated in susceptible individuals by ingestion of gluten. We recently reported that gliadin-specific T cells can be found in the small intestinal mucosa of CD patients, and that a preponderance of these T cells was restricted by the CD-associated DQ(alpha 1*0501,beta 1*0201)heterodimer. Here we report studies on whether the same is found for gliadin specific T cells in the peripheral blood of CD patients. T-cell responses towards gluten antigens in vitro were found for both most CD patients and healthy controls. Gluten-specific T-cell clones (TCC) were established from four CD patients. Although a large proportion of these TCC were restricted by DQ molecules, including the CD-associated DQ(alpha 1*0501,beta 1*0201) heterodimer, several were restricted instead by DR or DP molecules. Thus, gluten-derived peptides can be presented to T cells by several different HLA class-II molecules, and the preferential DQ(alpha 1*0501,beta 1*0201) restriction of gluten-specific T cells in the small intestinal mucosa of CD patients is less pronounced than for similar T cells in the peripheral blood. |
| Document Type: Article |
| Language: English |
| Reprint Address: GJERTSEN, HA (reprint author), NATL HOSP NORWAY, INST TRANSPLANTAT IMMUNOL, N-0027 OSLO, NORWAY |
Addresses:
1. BUSKERUD CENT HOSP, DEPT PEDIAT, DRAMMEN, NORWAY |
| Publisher: BLACKWELL SCIENCE LTD, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL |
| Subject Category: Immunology |
| IDS Number: NP385 |
| ISSN: 0300-9475 |
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