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| POTENTIAL-INDUCED CHANGES IN INTRACELLULAR PH |
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| Author(s): LYALL V, BIBER TUL |
| Source: AMERICAN JOURNAL OF PHYSIOLOGY Volume: 266 Issue: 5 Pages: F685-F696 Part: Part 2 Published: MAY 1994 |
| Times Cited: 18 References: 130 |
| Abstract: In a variety of cell types and tissues there is a strong dependence of intracellular pH (pH(i)) on membrane potential (V-m). Since cell V-m values can be altered by hormones, ion concentrations, and changes in membrane conductances, the potential-dependent changes in pH(i) may serve as an important mechanism by which cells can alter their pH(i) to an environmental stimulus. The H+ Aux across the cell membranes is thought to take place via putative H+ channels that are blocked by low concentrations of divalent metal ions. However, in Na+-transporting epithelia, a major part of the H+ flux seems to be via the amiloride-sensitive apical Na+ channels, which are not sensitive to divalent metal ions. The H+ flux via the Na+ channel can be modulated by natriferic hormones and intracellular second messengers. The H+-conductive pathways may play an important role in signal transduction in some cells. |
| Document Type: Review |
| Language: English |
| Reprint Address: LYALL, V (reprint author), VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PHYSIOL, SANGER HALL 3009, 1101 E MARSHALL ST, RICHMOND, VA 23298 USA |
| Publisher: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Physiology |
| IDS Number: NP996 |
| ISSN: 0002-9513 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |