| | |  | | | | Record from Web of Science® | | | | | | |
| ASSOCIATION BETWEEN ATOPY AND VARIANTS OF THE BETA-SUBUNIT OF THE HIGH-AFFINITY IMMUNOGLOBULIN-E RECEPTOR |
|
|
| Author(s): SHIRAKAWA T, LI AR, DUBOWITZ M, DEKKER JW, SHAW AE, FAUX JA, RA CS, COOKSON WOCM, HOPKIN JM |
| Source: NATURE GENETICS Volume: 7 Issue: 2 Pages: 125-130 Published: JUN 1994 |
| Times Cited: 314 References: 56 |
| Abstract: The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q. |
| Document Type: Article |
| Language: English |
Addresses:
1. JOHN RADCLIFFE HOSP, NUFFIELD DEPT MED, OXFORD OX3 9DU, ENGLAND
2. JUNTENDO UNIV, SCH MED, DEPT IMMUNOL, TOKYO 113, JAPAN
3. CHURCHILL HOSP, OSLER CHEST UNIT, OXFORD OX3 7LJ, ENGLAND |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: NQ037 |
| ISSN: 1061-4036 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |