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| AUTOLOGOUS TRANSPLANTS FOR CHRONIC MYELOGENOUS LEUKEMIA - RESULTS FROM 8 TRANSPLANT GROUPS |
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| Author(s): MCGLAVE PB, DEFABRITIIS P, DEISSEROTH A, GOLDMAN J, BARNETT M, REIFFERS J, SIMONSSON B, CARELLA A, AEPPLI D |
| Source: LANCET Volume: 343 Issue: 8911 Pages: 1486-1488 Published: JUN 11 1994 |
| Times Cited: 184 References: 22 |
| Abstract: Chronic myelogenous leukaemia (CML) can be cured by donor marrow transplant. Unfortunately, suitably HLA-matched related or unrelated donors are not available for the majority of patients. Transplant of stem cells derived from a patient's own marrow or peripheral blood (autologous transplant) avoids the need for an HLA-matched donor, is associated with a less complicated and shorter hospital course than donor transplantation, and has been successful in the treatment of other haematological malignancies. We report results of autologous transplants in 200 patients with CML at eight marrow transplant centres over seven yeats. This is the first multicentre analysis of autologous transplants for CML and reports on the largest number of patients studied to date. We show that autologous transplants provide a plateau in the survival curve not observed in conventional treatments. Autologous transplants are associated with a high engraftment rate, low mortality, and prompt return of both younger and older patients to normal activity levels.
Our results suggest that autologous transplants provide an alternative to conventional treatment in the care of patients not eligible for donor transplant.
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| Document Type: Article |
| Language: English |
| Reprint Address: MCGLAVE, PB (reprint author), UNIV MINNESOTA, SCH MED, DEPT MED, MARROW TRANSPLANT PROGRAM, MINNEAPOLIS, MN 55455 USA |
Addresses:
1. INST HEMATOL, ROME, ITALY
2. MD ANDERSON CANC CTR, DEPT HEMATOL, HOUSTON, TX 77030 USA
3. HAMMERSMITH HOSP, DEPT HAEMATOL, LONDON, ENGLAND
4. VANCOUVER GEN HOSP, LEUKEMIA & BONE MARROW TRANSPLANTAT PROGRAM, VANCOUVER, BC CANADA
5. HOSP HAUT LEVEQUE, UNITE GREFFE, BORDEAUX, FRANCE
6. UNIV UPPSALA HOSP, DEPT MED, UPPSALA, SWEDEN
7. OSPED SAN MARTINO GENOVA, GENOA, ITALY
8. UNIV MINNESOTA, SCH PUBL HLTH, MINNEAPOLIS, MN 55455 USA |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: NQ415 |
| ISSN: 0140-6736 |
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