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| LOSS OF HETEROZYGOSITY FOR 10Q22-10QTER IN MALIGNANT-MELANOMA PROGRESSION |
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| Author(s): HERBST RA, WEISS J, EHNIS A, CAVENEE WK, ARDEN KC |
| Source: CANCER RESEARCH Volume: 54 Issue: 12 Pages: 3111-3114 Published: JUN 15 1994 |
| Times Cited: 102 References: 22 |
| Abstract: Karyotypic and molecular data indicate that genetic events involving the chromosome region 10q22-10qter may be related to tumorigenesis in malignant melanoma. To test this we analyzed 10 polymorphic microsatellite repeats in the region 10q22-qter, using a polymerase chain reaction-based assay for loss of heterozygosity and DNA isolated from normal and tumor tissue from 26 individuals with malignant melanoma. The samples included 19 paired normal and malignant tissues representing various stages of melanoma as well as 7 cases in which samples from at least 2 different points in time during tumor progression were available. Our findings indicate that loss of heterozygosity of 10q22-10qter is a frequent event, that the observed loss of heterozygosity does not result from whole chromosome loss, and that it is associated with tumor progression. Finally, the appearance of new alleles in two of the tumors may indicate the involvement of DNA replication errors in melanoma analogous to such events in other tumor types. |
| Document Type: Note |
| Language: English |
| Reprint Address: HERBST, RA (reprint author), UNIV CALIF SAN DIEGO, LUDWIG INST CANC RES, SAN DIEGO BRANCH, 9500 GILMAN DR, LA JOLLA, CA 92093 USA |
Addresses:
1. UNIV CALIF SAN DIEGO, CTR MOLEC GENET, LA JOLLA, CA 92093 USA
2. UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
3. UNIV HEIDELBERG, FAK KLIN MED MANNHEIM, HAUTKLIN MANNHEIM, D-68135 MANNHEIM, GERMANY |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: NQ724 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |