| | |  | | | | Record from Web of Science® | | | | | | |
| STRUCTURAL MECHANISMS FOR DOMAIN MOVEMENTS IN PROTEINS |
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| Author(s): GERSTEIN M, LESK AM, CHOTHIA C |
| Source: BIOCHEMISTRY Volume: 33 Issue: 22 Pages: 6739-6749 Published: JUN 7 1994 |
| Times Cited: 477 References: 102 |
| Abstract: We survey all the known instances of domain movements in proteins for which there is crystallographic evidence for the movement. We explain these domain movements in terms of the repertoire of low-energy conformation changes that are known to occur in proteins. We first describe the basic elements of this repertoire, hinge and shear motions, and then show how the elements of the repertoire can be combined to produce domain movements. We emphasize that the elements used in particular proteins are determined mainly by the structure of the interfaces between the domains. |
| Document Type: Review |
| Language: English |
Addresses:
1. UNIV CAMBRIDGE, DEPT HAEMATOL, MRC, MOLEC BIOL LAB, CAMBRIDGE CB2 2QH, ENGLAND
2. CAMBRIDGE CTR PROT ENGN, CAMBRIDGE CB2 2QH, CAMBS ENGLAND |
| Publisher: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: NQ730 |
| ISSN: 0006-2960 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |