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| TEMPORAL ASSOCIATION OF CELLULAR IMMUNE-RESPONSES WITH THE INITIAL CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SYNDROME |
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| Author(s): KOUP RA, SAFRIT JT, CAO YZ, ANDREWS CA, MCLEOD G, BORKOWSKY W, FARTHING C, HO DD |
| Source: JOURNAL OF VIROLOGY Volume: 68 Issue: 7 Pages: 4650-4655 Published: JUL 1994 |
| Times Cited: 1,532 References: 53 |
| Abstract: Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8(+) cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and Env were detected at or within 3 weeks of presentation in four of the five patients and were detected in all five patients by 3 to 6 months after presentation. The one patient with an absent initial CTL response had prolonged symptoms, persistent viremia, and low CD4(+) T cell count. Neutralizing antibody activity was absent at the time of presentation in all five patients. These findings suggest that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and indicate a role for CTL in protective immunity to HIV-1 in vivo. |
| Document Type: Note |
| Language: English |
| Reprint Address: KOUP, RA (reprint author), AARON DIAMOND AIDS RES CTR, 455 1ST AVE, 7TH FLOOR, NEW YORK, NY 10016 USA |
Addresses:
1. NYU, SCH MED, NEW YORK, NY USA
2. NEW ENGLAND DEACONESS HOSP, BOSTON, MA 02215 USA |
| Publisher: AMER SOC MICROBIOLOGY, 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 |
| Subject Category: Virology |
| IDS Number: NQ763 |
| ISSN: 0022-538X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |