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| A GENETIC-MAP OF THE MOUSE WITH 4,006 SIMPLE SEQUENCE LENGTH POLYMORPHISMS |
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| Author(s): DIETRICH WF, MILLER JC, STEEN RG, MERCHANT M, DAMRON D, NAHF R, GROSS A, JOYCE DC, WESSEL M, DREDGE RD, MARQUIS A, STEIN LD, GOODMAN N, PAGE DC, LANDER ES |
| Source: NATURE GENETICS Volume: 7 Issue: 2 Special Issue: Sp. Iss. SI Pages: 220-245 Published: JUN 1994 |
| Times Cited: 569 References: 25 |
| Abstract: We have constructed a genetic map of the mouse genome containing 4,006 simple sequence length polymorphims (SSLPs). The map provides an average spacing of 0.35 centiMorgans (cM) between markers, corresponding to about 750 kb. Approximately 90% of the genome lies within 1.1 cM of a marker and 99% lies within 2.2 cM. The markers have an average polymorphism rate of 50% in crosses between laboratory strains. The markers are distributed in a relatively uniform fashion across the genome, although some deviations from randomness can be detected. In particular, there is a significant underrepresentation of markers on the X chromosome. This map represents the two-thirds point toward our goal of developing a mouse genetic map containing 6,000 SSLPs. |
| Document Type: Article |
| Language: English |
| Reprint Address: DIETRICH, WF (reprint author), MIT, WHITEHEAD INST BIOMED RES, CTR GENOME RES, 9 CAMBRIDGE CTR, CAMBRIDGE, MA 02142 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: NQ898 |
| ISSN: 1061-4036 |
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