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| A NEW GENE CODING FOR A DIFFERENTIATION ANTIGEN RECOGNIZED BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES ON HLA-A2 MELANOMAS |
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| Author(s): COULIE PG, BRICHARD V, VANPEL A, WOLFEL T, SCHNEIDER J, TRAVERSARI C, MATTEI S, DEPLAEN E, LURQUIN C, SZIKORA JP, RENAULD JC, BOON T |
| Source: JOURNAL OF EXPERIMENTAL MEDICINE Volume: 180 Issue: 1 Pages: 35-42 Published: JUL 1 1994 |
| Times Cited: 662 References: 28 |
| Abstract: It has been reported previously that antitumor cytolytic T lymphocyte (CTL) clones can be isolated from blood lymphocytes of HLA-A2 melanoma patients, after stimulation in vitro with autologous tumor cells, and that some of these CTL clones lyse most HLA-A2 melanomas. A first antigen recognized by such CTL clones was previously shown to be encoded by the tyrosinase gene. We report here the identification of another gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that are restricted by HLA-A2. The gene, designated Melan-A, is unrelated to any known gene. It is 18 kb long and comprises five exons. Like the tyrosinase gene, it is expressed in most melanoma tumor samples and, among normal cells, only in melanocytes. |
| Document Type: Article |
| Language: English |
| Reprint Address: COULIE, PG (reprint author), LUDWIG INST CANC RES, BRUSSELS BRANCH, 74 AVE HIPPOCRATE, B-1200 BRUSSELS, BELGIUM |
Addresses:
1. UNIV CATHOLIQUE LOUVAIN, CELLULAR GENET UNIT, B-1200 BRUSSELS, BELGIUM
2. UNIV MAINZ, MED KLIN & POLIKLIN 1, D-55131 MAINZ, GERMANY
3. IST SCI SAN RAFFAELE, DIPARTIMENTO EMATOL, I-20100 MILAN, ITALY |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Immunology; Medicine, Research & Experimental |
| IDS Number: NR989 |
| ISSN: 0022-1007 |
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