| | |  | | | | Record from Web of Science® | | | | | | |
| CYTOGENIC ABNORMALITIES OF SMALL ROUND-CELL TUMORS |
|
|
| Author(s): BOWN NP, REID MM, MALCOLM AJ, DAVISON EV, CRAFT AW, PEARSON ADJ |
| Source: MEDICAL AND PEDIATRIC ONCOLOGY Volume: 23 Issue: 2 Pages: 124-129 Published: 1994 |
| Times Cited: 18 References: 19 |
| Abstract: Between 1987 and 1991, cytogenetic studies were carried out on small round cell tumours of 68 patients from the Northern Health Region of England. Clonal chromosome abnormalities were found in 30, comprising 15 neuroblastomas, 7 Ewing's tumours, 7 rhabdomyosarcomas, and 1 granular cell tumour. Characteristic rearrangements were found in five cases of Ewing's tumour [all with translocation t(11;22) (q24;q12)] and in four cases of rhabdomyosarcoma [all with evidence of translocation t(2;13) (q35-37;q14)]. In one case of Ewing's tumour and three of rhabdomyosarcoma, the cytogenetic findings were important in diagnosis. Within the neuroblastomas, examples were found of hyperdiploidy, lp rearrangements, double minute chromosomes, and homogeneously staining regions, but too few cases were available for prognostic associations to be assessed. Our findings confirm the diagnostic importance of chromosome abnormalities in small round cell tumours and indicate that cytogenetic analysis should be an intrinsic part of the initial investigations of all patients with such tumours. (C) 1994 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOWN, NP (reprint author), UNIV NEWCASTLE UPON TYNE, DEPT HUMAN GENET, 19 CLAREMONT PL, NEWCASTLE UPON TYNE NE2 4AA, ENGLAND |
Addresses:
1. UNIV NEWCASTLE UPON TYNE, DEPT CHILD HLTH, NEWCASTLE UPON TYNE NE1 7RU, TYNE & WEAR ENGLAND
2. ROYAL VICTORIA INFIRM, DEPT PATHOL, NEWCASTLE UPON TYNE NE1 4LP, TYNE & WEAR ENGLAND
3. ROYAL VICTORIA INFIRM, DEPT HAEMATOL, NEWCASTLE UPON TYNE NE1 4LP, TYNE & WEAR ENGLAND |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology; Pediatrics |
| IDS Number: NT357 |
| ISSN: 0098-1532 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |