| | |  | | | | Record from Web of Science® | | | | | | |
| DAX, A LOCUST HOX GENE-RELATED TO FUSHI-TARAZU BUT SHOWING NO PAIR-RULE EXPRESSION |
|
|
| Author(s): DAWES R, DAWSON I, FALCIANI F, TEAR G, AKAM M |
| Source: DEVELOPMENT Volume: 120 Issue: 6 Pages: 1561-1572 Published: JUN 1994 |
| Times Cited: 119 References: 67 |
| Abstract: We describe an unusual Antennapedia class homeobox gene from the grasshopper Schistocerca gregaria (Orthoptera, African Plague Locust). Its sequence is not sufficiently similar to that of any other insect Hem-Hox gene to identify it unambiguously, but short conserved elements suggest a relationship to the segmentation gene fushi-tarazu, (ftz). We term it Sg Dax (divergent Antennapedia class homeobox gene). Antibodies raised against the protein encoded by this gene reveal two phases of expression during embryogenesis. In the early embryo, it is a marker for the posterior part of the forming embryonic primordium, and subsequently for the posterior part of the growing germ band. In older embryos, it labels a subset of neural precursor cells in each trunk segment, very similar to that defined by the expression of fushi tarazu (ftz) in Drosophila. We suggest that Schistocerca Dax and Drosophila ftz are homologous members of a gene family whose members are diverging relatively rapidly, both in terms of sequence and role in early development. |
| Document Type: Article |
| Language: English |
| Reprint Address: DAWES, R (reprint author), WELLCOME CRC INST, TENNIS COURT RD, CAMBRIDGE CB2 1QR, CAMBS ENGLAND |
Addresses:
1. DEPT GENET, CAMBRIDGE CB2 1QR, CAMBS ENGLAND |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS, ENGLAND CB4 4DL |
| Subject Category: Developmental Biology |
| IDS Number: NT555 |
| ISSN: 0950-1991 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |