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| EPIGENETIC LESIONS AT THE H19 LOCUS IN WILMS-TUMOR PATIENTS |
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| Author(s): MOULTON T, CRENSHAW T, HAO Y, MOOSIKASUWAN J, LIN N, DEMBITZER F, HENSLE T, WEISS L, MCMORROW L, LOEW T, KRAUS W, GERALD W, TYCKO B |
| Source: NATURE GENETICS Volume: 7 Issue: 3 Pages: 440-447 Published: JUL 1994 |
| Times Cited: 246 References: 40 |
| Abstract: To test the potential role of H19 as a tumour suppressor gene we have examined its expression and DNA methylation in Wilms' tumours (WTs). In most WTs (18/25), H19 RNA was reduced at least 20-fold from fetal kidney levels. Of the expression-negative tumours ten retained 11p15.5 heterozygosity: in nine of these, H19 DNA was biallelically hypermethylated and in two cases hypermethylation locally restricted to H19 sequences was also present in the non-neoplastic kidney parenchyma. IGF2 mRNA was expressed in most but not all WTs and expression patterns were consistent with IGF2/H19 enhancer competition without obligate inverse coupling. These observations implicate genetic and epigenetic inactivation of H19 in Wilms' tumorigenesis. |
| Document Type: Article |
| Language: English |
Addresses:
1. COLUMBIA UNIV, COLL PHYS & SURG, DEPT PATHOL, DIV ONCOL, NEW YORK, NY 10032 USA
2. COLUMBIA UNIV, COLL PHYS & SURG, DEPT PEDIAT, DIV PEDIAT HEMATOL ONCOL, NEW YORK, NY 10032 USA
3. COLUMBIA UNIV, COLL PHYS & SURG, DEPT PATHOL, DIV NEUROPATHOL, NEW YORK, NY 10032 USA
4. COLUMBIA UNIV, COLL PHYS & SURG, DEPT SURG, DIV PEDIAT SURG, NEW YORK, NY 10032 USA
5. CITY HOPE NATL MED CTR, DEPT PATHOL, DUARTE, CA 91010 USA
6. UNIV MED & DENT NEW JERSEY, COOPER HOSP, MED CTR, DEPT PEDIAT, DIV HEMATOL ONCOL, CAMDEN, NJ 08103 USA
7. SO ILLINOIS UNIV, SCH MED, DEPT PEDIAT, DIV PEDIAT HEMATOL ONCOL, SPRINGFIELD, IL 62702 USA
8. SCOTTISH RITE CHILDRENS HOSP, DEPT PEDIAT, DIV GENET, ATLANTA, GA 30342 USA
9. MEM SLOAN KETTERING CANC CTR, DEPT PATHOL, NEW YORK, NY 10021 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: NU306 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |