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| IMMUNODOMINANT EPITOPES OF GLUTAMIC-ACID DECARBOXYLASE-65 AND DECARBOXYLASE-67 IN INSULIN-DEPENDENT DIABETES-MELLITUS |
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| Author(s): LOHMANN T, LESLIE RDG, HAWA M, GEYSEN M, RODDA S, LONDEI M |
| Source: LANCET Volume: 343 Issue: 8913 Pages: 1607-1608 Published: JUN 25 1994 |
| Times Cited: 89 References: 9 |
| Abstract: To find the dominant epitopes of a major autoantigen in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD), we studied the reactivity of peripheral blood T lymphocytes with peptides covering both major isoforms. A significant response to GAD 65 or GAD 67 peptides was detected in 13 of 15 IDDM patients and in 9 of 10 normal controls. Controls most frequently recognised the central region of GAD 65 (residues 161-243). IDDM patients preferentially recognised residues 473-555 (p < 0.03). T-cell responses to GAD 67 peptides were similar in IDDM patients and controls. T lymphocytes from IDDM patients recognise a distinct dominant epitope of GAD, which may be an important target for the disease process. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL, DEPT DIABET & METAB, LONDON EC1A 7BE, ENGLAND
2. KENNEDY INST, LONDON W6, ENGLAND
3. CHIRON MIMOTOPES, CLAYTON, VIC AUSTRALIA |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: NU354 |
| ISSN: 0140-6736 |
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