| | |  | | | | Record from Web of Science® | | | | | | |
| CEREBRAL DEMYELINATION WITH 5-FLUOROURACIL AND LEVAMISOLE |
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| Author(s): FASSAS ABT, GATTANI AM, MORGELLO S |
| Source: CANCER INVESTIGATION Volume: 12 Issue: 4 Pages: 379-383 Published: 1994 |
| Times Cited: 23 References: 10 |
| Abstract: We report a patient who developed multifocal cerebral demyelination with the use of 5-fluorouracil, levamisole, and leucovorin as adjuvant treatment for intestinal adenocarcinoma. The clinical features were acute confusion, restlessness, ataxia, and slurred speech. Magnetic resonance imaging revealed multifocal enhancing white matter lesions. Brain biopsy showed a well-demarcated area of demyelination in cerebral white matter. The patient improved clinically and radiologically after cessation of chemotherapy and a short course of steroids. There have been only 4 previously reported cases of multifocal leukoencephalopathy related to the use of combination 5-fluorouracil and levamisole. The extensive use of these agents as adjuvant treatment for colorectal carcinoma may result in more frequent recognition of this form of neurological toxicity. |
| Document Type: Article |
| Language: English |
Addresses:
1. MT SINAI MED CTR, JERALD H RUTTENBERG CANC CTR, DEPT NEOPLAST DIS, NEW YORK, NY 10029 USA
2. MT SINAI MED CTR, DEPT PATHOL, DIV NEUROPATHOL, NEW YORK, NY 10029 USA |
| Publisher: MARCEL DEKKER INC, 270 MADISON AVE, NEW YORK, NY 10016 |
| Subject Category: Oncology |
| IDS Number: NX897 |
| ISSN: 0735-7907 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |