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| MICE WITH TARGETED DISRUPTIONS IN THE PARALOGOUS GENES HOXA-3 AND HORD-3 REVEAL SYNERGISTIC INTERACTIONS |
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| Author(s): CONDIE BG, CAPECCHI MR |
| Source: NATURE Volume: 370 Issue: 6487 Pages: 304-307 Published: JUL 28 1994 |
| Times Cited: 179 References: 22 |
| Abstract: THE Hox genes encode transcription factors which mediate the formation of the mammalian body plan along the anteroposterior and appendicular axes(1-15). Paralogous Hox genes within the separate linkage groups are closely related with respect to DNA sequence and expression(16,17), suggesting that they could have at least partially redundant functions. We showed previously that mice homozygous for independent targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 had no defects in common(1,8). But our current analysis of double mutants has revealed strong, dosage-dependent interactions between these genes. We report here that in hoxd-3(-) homozygotes the first cervical vertebra, the atlas, is homeotically transformed to the adjacent anterior structure. Unexpectedly, in double mutants, rather than observing a more extensive homeotic transformation, the entire atlas is deleted. These observations are interpreted in terms of a model in which these Hox genes differentially regulate the proliferation rates of the appropriate sets of precursor cells. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV UTAH, SCH MED, HOWARD HUGHES MED INST, DEPT HUMAN GENET, SALT LAKE CITY, UT 84112 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: NZ229 |
| ISSN: 0028-0836 |
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