| | |  | | | | Record from Web of Science® | | | | | | |
| THE 2-HYBRID SYSTEM - AN ASSAY FOR PROTEIN-PROTEIN INTERACTIONS |
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| Author(s): FIELDS S, STERNGLANZ R |
| Source: TRENDS IN GENETICS Volume: 10 Issue: 8 Pages: 286-292 Published: AUG 1994 |
| Times Cited: 406 References: 40 |
| Abstract: The two-hybrid system is a yeast-based genetic assay for detecting protein-protein interactions. It can be used to identify proteins that bind to a protein of interest, or to delineate domains or residues critical for an interaction. Variations on this methodology have been developed to clone genes that encode DNA-binding proteins, to identify, peptides that bind to a protein and, potentially, to screen for drugs. |
| Document Type: Review |
| Language: English |
| Reprint Address: FIELDS, S (reprint author), SUNY STONY BROOK, DEPT MOLEC GENET & MICROBIOL, STONY BROOK, NY 11794 USA |
Addresses:
1. SUNY STONY BROOK, DEPT BIOCHEM & CELL BIOL, STONY BROOK, NY 11794 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: NZ537 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |