| | |  | | | | Record from Web of Science® | | | | | | |
| PREFERENTIAL NUCLEOSOME ASSEMBLY AT DNA TRIPLET REPEATS FROM THE MYOTONIC-DYSTROPHY GENE |
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| Author(s): WANG YH, AMIRHAERI S, KANG S, WELLS RD, GRIFFITH JD |
| Source: SCIENCE Volume: 265 Issue: 5172 Pages: 669-671 Published: JUL 29 1994 |
| Times Cited: 174 References: 25 |
| Abstract: The expansion of CTG repeats in DNA occurs in or near genes involved in several human diseases, including myotonic dystrophy and Huntington's disease. Nucleosomes, the basic structural element of chromosomes, consist of 146 base pairs of DNA coiled about an octamer of histone proteins and mediate general transcriptional repression. Electron microscopy was used to examine in vitro the nucleosome assembly of DNA containing repeating CTG triplets. The efficiency of nucleosome formation increased with expanded triplet blocks, suggesting that such blocks may repress transcription through the creation of stable nucleosomes. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV N CAROLINA, LINEBERGER CANC RES CTR, CHAPEL HILL, NC 27599 USA
2. TEXAS A&M UNIV, INST BIOSCI & TECHNOL, HOUSTON, TX 77030 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: NZ538 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |