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| IDENTIFICATION OF NOVEL GENES, SYT AND SSX, INVOLVED IN THE T(X18)(P11.2Q11.2) TRANSLOCATION FOUND IN HUMAN SYNOVIAL SARCOMA |
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| Author(s): CLARK J, ROCQUES PJ, CREW AJ, GILL S, SHIPLEY J, CHAN AML, GUSTERSON BA, COOPER CS |
| Source: NATURE GENETICS Volume: 7 Issue: 4 Pages: 502-508 Published: AUG 1994 |
| Times Cited: 352 References: 34 |
| Abstract: Human synovial sarcomas contain a recurrent and specific chromosomal translocation t(X;18)(p11.2;q11.2). By screening a synovial sarcoma cDNA library with a yeast artificial chromosome spanning the X chromosome breakpoint, we have indentified a hybrid transcript that contains 5' sequences (designated SYT) mapping to chromosome 18 and 3' sequences (designated SSX) mapping to chromosome X. An SM probe detected genomic rearrangements in 10/13 synovial sarcomas. Sequencing of cDNA clones shows that the normal SM gene encodes a protein rich in glutamine, proline and glycine, and indicates that in synovial sarcoma rearrangement of the SYT gene results in the formation of an STT-SSX fusion protein. Both SYT and SSX failed to exhibit significant homology to known gene sequences. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST CANC RES, HADDOW LABS, DEPT MOLEC CARCINOGENESIS, SUTTON SM2 5NG, SURREY ENGLAND
2. ROCKEFELLER UNIV, MT SINAI SCH MED, RUTTENBERG CANC CTR, NEW YORK, NY 10021 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: PA832 |
| ISSN: 1061-4036 |
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