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| GENETIC-ANALYSIS OF COLON-CANCER SUSCEPTIBILITY IN MICE |
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| Author(s): JACOBY RF, HOHMAN C, MARSHALL DJ, FRICK TJ, SCHLACK S, BRODA M, SMUTKO J, ELLIOTT RW |
| Source: GENOMICS Volume: 22 Issue: 2 Pages: 381-387 Published: JUL 15 1994 |
| Times Cited: 55 References: 39 |
| Abstract: Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors, Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q. (C) 1994 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: JACOBY, RF (reprint author), UNIV WISCONSIN, SCH MED, GASTROENTEROL SECT, H6-516 CLIN SCI CTR, 600 HIGHLAND AVE, MADISON, WI 53792 USA |
Addresses:
1. UNIV WISCONSIN, SCH MED, DEPT MED, MADISON, WI 53792 USA
2. UNIV WISCONSIN, SCH MED, CTR COMPREHENS CANC, MADISON, WI 53792 USA
3. WILLIAM S MIDDLETON MEM VET ADM MED CTR, MADISON, WI 53705 USA
4. ROSWELL PK CANC INST, DEPT MOLEC & CELLULAR BIOL, BUFFALO, NY 14263 USA |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biotechnology & Applied Microbiology; Genetics & Heredity |
| IDS Number: PB571 |
| ISSN: 0888-7543 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |