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| PERIPHERAL-BLOOD STEM-CELLS (PBSCS) COLLECTED AFTER RECOMBINANT GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) - AN ANALYSIS OF FACTORS CORRELATING WITH THE TEMPO OF ENGRAFTMENT AFTER TRANSPLANTATION |
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| Author(s): BENSINGER WI, LONGIN K, APPELBAUM F, ROWLEY S, WEAVER C, LILLEBY K, GOOLEY T, LYNCH M, HIGANO T, KLARNET J, CHAUNCEY T, STORB R, BUCKNER CD |
| Source: BRITISH JOURNAL OF HAEMATOLOGY Volume: 87 Issue: 4 Pages: 825-831 Published: AUG 1994 |
| Times Cited: 275 References: 29 |
| Abstract: Factors affecting mobilization and engraftment were analysed in 54 patients undergoing transplant using autologous PBSCs mobilized with high-dose recombinant granulocyte stimulating factor (rhG-CSF). Patients received 5-7d of rhG-CSF, 16 mu g/kg/d, administered subcutaneously. PBSCs were harvested by leukapheresis using automated continuous-flow blood cell separators beginning on day 4 of rhG-CSF, processing 10 litres of whole blood, for 2-6 consecutive days. Transplants were performed for the following diseases: breast cancer (n = 22), non-Hodgkin's lymphoma (n = 18), multiple myeloma (n = 7) and other (n = 7). Engraftment: was rapid with patients reaching a neutrophil count of 1 x 10(9)/l a median of 12 d (range 9-22) after transplant. Platelets > 20 x 10(9)/l independent of transfusion support were achieved a median of day 10 (range 7-60) after infusion. Multiple factors potentially influencing engraftment were examined using a Cox regression model. The number of CD34(+) cells per kg was highly correlated with the time to achievement of granulocyte and platelet recovery (P < 0.012, 0.0001). The use of a post-infusion growth factor and a radiation preparative regimen was important for neutrophil recovery, and a diagnosis of breast cancer was important for platelet recovery. In an analysis by linear regression of the logarithm of CD34(+) cells collected, lower age, marrow without disease, no prior radiation, and lower number of prior chemotherapy regimens, were important factors influencing larger numbers of CD34(+) cells in collections. |
| Document Type: Article |
| Language: English |
Addresses:
1. VET ADM MED CTR, SEATTLE, WA USA
2. UNIV WASHINGTON, SEATTLE, WA USA |
| Publisher: BLACKWELL SCIENCE LTD, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL |
| Subject Category: Hematology |
| IDS Number: PB740 |
| ISSN: 0007-1048 |
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