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| ISOLATION OF A DIVERGED HOMEOBOX GENE, MOX1, FROM THE BRCA1 REGION ON 17Q21 BY SOLUTION HYBRID CAPTURE |
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| Author(s): FUTREAL PA, COCHRAN C, ROSENTHAL J, MIKI Y, SWENSON J, HOBBS M, BENNETT LM, HAUGENSTRANO A, MARKS J, BARRETT JC, TAVTIGIAN SV, SHATTUCKEIDENS D, KAMB A, SKOLNICK M, WISEMAN RW |
| Source: HUMAN MOLECULAR GENETICS Volume: 3 Issue: 8 Pages: 1359-1364 Published: AUG 1994 |
| Times Cited: 39 References: 28 |
| Abstract: Using the technique of solution hybridization coupled with magnetic bead capture, we have isolated a novel homeobox-containing gene from the BRCA1 region of 17q21. This gene is the human homologue of the mouse Mox1 gene previously localized to a syntenic region of mouse chromosome 11. Multiple overlapping cDNAs of human MOX1 were identified using both a cosmid and a P1 genomic clone containing the microsatellite markers D17S750 and D17S858 which map within the BRCA1 region defined by D17S776 and D17S78. MOX1 expression was observed in a variety of normal tissues examined, including breast and ovary. Given that the gene contains a homeobox domain and has the potential to regulate growth and differentiation, MOX1 represents an attractive candidate for the BRCA1 gene. This possibility was investigated in a series of BRCA1 kindreds and primary sporadic breast tumors. No evidence for mutation was found in the coding sequence, making it unlikely that MOX1 is the BRCA1 gene. However, the widespread expression of MOX1 in non-embryonal tissues suggests a role in normal cell biology which warrants further study. |
| Document Type: Article |
| Language: English |
| Reprint Address: FUTREAL, PA (reprint author), NIEHS, MOLEC CARCINOGENESIS LAB, RES TRIANGLE PK, NC 27709 USA |
Addresses:
1. MYRIAD GENET INC, SALT LAKE CITY, UT 84108 USA
2. UNIV UTAH, MED CTR, DEPT MED INFORMAT, SALT LAKE CITY, UT 84132 USA
3. UNIV UTAH, MED CTR, DEPT HUMAN GENET, SALT LAKE CITY, UT 84132 USA
4. DUKE UNIV, MED CTR, DEPT SURG, DURHAM, NC 27710 USA |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Genetics & Heredity |
| IDS Number: PC827 |
| ISSN: 0964-6906 |
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